![]() ![]() By contrast, JYNNEOS TM is approved for monkeypox (but only for persons 18 years old and up). Note: ACAM2000® isn’t approved for monkeypox, it’s just authorized for use with monkeypox under an IND protocol. And remember, ACAM can replicate, so there’s a chance of vaccinia spreading from a vaccinated to an unvaccinated person. Like any other public health intervention, the first thing you need to do is look at the risks and benefits. ACAM2000® can cause serious reactions including myocarditis and/or pericarditis, encephalitis, encephalomyelitis, encephalopathy, progressive vaccinia, generalized vaccinia, severe skin infections, erythema, eczema, blindness, and fetal death in pregnant women.įor example, based on clinical trials, myocarditis or pericarditis (such as chest pain, raised troponin/cardiac enzymes, or ECG abnormalities) occur in 5. HHS will allow states to order ACAM2000® from the stockpile to increase their vaccine supply fast, but it appears that very few if any states are doing so. Why Not Just Order ACAM2000 from the Stockpile to Increase the Supply Fast? I can’t find how many doses the SNS has for this one. Aventis Pasteur Smallpox Vaccine (APSV) is also in the stockpile but this one is just an investigational vaccine that can only be used in a smallpox emergency under the right regulatory mechanism (Emergency Use Authorization). ![]() There are only about 65,000 doses of JYNNEOS TM in the SNS – although HHS has ordered 2.5 million more doses from Bavarian Nordic A/S (a fairly small manufacturer). For that reason, in November 2021, the ACIP unanimously voted in favor of JYNNEOS as an alternative to ACAM2000 for primary vaccination and booster doses for both monkeypox and smallpox. It’s also better tolerated and has fewer nonserious side effects. It isn’t associated with any cardiac adverse events like ACAM2000®. JYNNEOS TM is also a live virus but it’s not “replication-competent” which means that it can’t replicate like ACAM can. JYNNEOS TM – is the approved for both smallpox & monkeypox – but only for persons 18 years old and up.There are more than 100 million doses of ACAM2000® in the SNS. There’s also documentation that vaccinia can spread from person-to-person post-vaccination (ACAM can replicate). While the vaccine is fairly safe, it can cause myocarditis and/or pericarditis after administration (at an approximate rate of 5.). It’s a “replication-competent live virus” ( Vaccinia virus) which means that it’s a live attenuated virus that replicates. ACAM2000® – is approved for smallpox in persons over 1 year-old & is authorized under an Investigational New Drug protocol for monkeypox.The Strategic National Stockpile has three kinds of smallpox/monkeypox vaccines that are either approved or authorized for monkeypox: The answer lies in what kind and how much of each of the smallpox vaccines are in the stockpile. So, if the smallpox vaccine works for monkeypox, and the smallpox vaccine is included in the SNS, how come the monkeypox vaccine is in such short supply? Note: Arizona has only received about 2,000 doses of JYNNEOS TM with 1500 doses on the way the way later this week. ![]() ![]() Smallpox was eradicated in 1979, but the smallpox vaccine has been included in the Strategic National Stockpile as a safeguard in case the smallpox virus is accidently or intentionally released from one of the two secure laboratories where it exists (at the CDC and the Russian Centre for Research on Virology and Biotechnology in Koltsovo, Russia). and can be drawn upon at the order of the HHS Secretary. Those stockpiles are stored in secret warehouses around the U.S. has had a Strategic National Stockpile (SNS) of different kinds of therapeutics, vaccines and other materials that can be used in a public health emergency. Past data from Africa suggests that the newest smallpox/monkeypox vaccine (called JYNNEOS TM) is about 85% effective in preventing monkeypox (vaccination promptly after a monkeypox exposure may help prevent the disease or make symptoms less severe).įor many years, the U.S. Because Monkeypox virus is closely related to the virus that causes smallpox, the smallpox vaccine can protect people from getting monkeypox. ![]()
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